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Well, Susan just lost my vote. GUCCI Absence of SIRT1 in hippocampal neurons of knock-out mice does not impact normal gross brain anatomy. A , Representative images of SIRT1-KO and WT Nissl-stained coronal brain sections. SIRT1-KO brains show normal gross neuroanatomy. B , Immunofluorescence of coronal brain sections from SIRT1-KO and WT mice. SIRT1 and NeuN are colocalized in WT hippocampal neurons in different areas, including the dentate gyrus, CA1, and CA3. SIRT1-KO sections show absence of SIRT1 in hippocampal neurons yet unaltered NeuN staining.
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Sticky Post There is zero discussion in the public square of the interest rate risk on this, the relative role of the City’s aggressive use of Certificates of Participation (COPs -debt the city incurs without going to the voters), the impact of going from the 15 year bond typically used to the 20 bonds, and City’s horrendous record of getting projects done on budget. No discussion of the city’s overall debt limits, and what is appropriate given the economic health of our residents and businesses.
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