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Five burst of 3 × 100 Hz stimulation evokes LTP in both genotypes, whereas 10 bursts of 10 × 100 Hz trains stimulation leads to a long-lasting form of LTP in control but not in SIRTI-KO mouse. D , EPSP slopes averages during the first 2 min after TBS (short-term potentiation) were similar in both genotypes. E , EPSP slopes averages 30–40 min after applying the 10 × 10 TBS protocol show significant differences in LTP induction in WT animals compared with SIRT1-KO mice (*p < 0.05, t test). 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