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Policies and Disclosures Treasurer Walker Stapleton on Why He Should Be Colorado's... Overexpression of SIRT1 in hippocampus does not alter LTP or associative memory. A , Western blot shows ∼16-fold SIRT1 protein increase in hippocampus of NeSTO mice compared with control Nestin–Cre animals. The numbers below show SIRT1 levels relative to actin. B , I/O curve of field EPSP slope versus current input (microamperes) is shifted to the left in NeSTO mice (n = 14; gray circles) compared with Nestin–Cre (n = 10; black circles; p < 0.0001, two-way ANOVA), suggesting increased basal synaptic excitability. C , Paired-pulse facilitation reveals normal presynaptic events in NeSTO mice (n = 5 each genotype). D , Similar LTP was elicited by 5 × 3 and 10 × 10 TBS (EPSP slopes; n = 7 each genotype) in mice overexpressing wild-type or increased levels of SIRT1. E, F , Fear conditioning to context ( E ) or tone ( F ) in Nestin–Cre (n = 14) and NeSTO animals (n = 18) show similar associative learning capacities in both strains. Data represent means ± SEM.
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1 Likes 3 plus ones JNeurosci Print ISSN: 0270-6474 Online ISSN: 1529-2401
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தமிழ் But they were just profanity-spewing University of Colorado film students struggling to make their first movie — Alferd Packer: The Musical — when Westword interviewed them back in 1993. As an anniversary present, we've resurrected the interview, which is now posted at www.westword.com.
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or Language: English Mature content filter: None Honeybees possess impressive cognitive abilities in the visual domain. With dedicated training a bee can extract spatial relations between elements and thus resolve tasks based on spatial configuration recognition or relational rules. Such cognitive performance implies important abstract abilities as configuration processing or learnt relations are transferrable to totally novel stimuli except from the relations linking the elements. In addition, bees preferentially use spatial configurations over local or low-level features to recognize objects and easily detect invariant relations between visual features within complex stimuli under unsupervised learning conditions. These recently reported demonstrations raise interesting questions about the biological significance for an insect brain to invest resources in such high-level cognitive skills.
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