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Absence of SIRT1 in hippocampal neurons of knock-out mice does not impact normal gross brain anatomy. A , Representative images of SIRT1-KO and WT Nissl-stained coronal brain sections. SIRT1-KO brains show normal gross neuroanatomy. B , Immunofluorescence of coronal brain sections from SIRT1-KO and WT mice. SIRT1 and NeuN are colocalized in WT hippocampal neurons in different areas, including the dentate gyrus, CA1, and CA3. SIRT1-KO sections show absence of SIRT1 in hippocampal neurons yet unaltered NeuN staining.
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The honeybee is a prominent model for studying the neural mechanisms underlying the formation and retrieval of associative memories (Giurfa 2007). Bees can learn stimulus-reward association in a range of elemental and non-elemental paradigms and they show the learned behavior very rapidly, typically after one or two rewarded trials (Pamir et al., 2014). We device a neural network simulation of the honeybee. Our model can reproduce the observed conditioned response (CR) behavior of honeybees in a variety of classical olfactory conditioning protocols. Our network model comprises peripheral olfactory receptor neurons, the antennal lobe (AL) network, the mushroom body (MB) and the lateral horn (LH). Plasticity is included at two levels, the AL and the MB. Plasticity in the interneurons of the AL allows for a de-correlation of odor response patterns within few trials, reducing generalization across odorants during training. Plasticity in the MB underlies the formation of associations. As a result the population of MB output neurons reliably encodes the value of a stimulus, in line with previous physiological results in honeybees (Strube-Bloss, Nawrot & Menzel, 2011; Menzel 2014) and flies (Aso et al., 2014); see also companion poster #240 (Nawrot et al., 2015). We show that predictions derived from our network model match a range of behavioral data from elemental and non-elemental learning paradigms, including absolute and differential conditioning, trace conditioning, and odor patterning, retaining the rapid learning dynamics observed in the animals’ behavior.
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(Click on names to see talk details) Juventus Leather In mammals, different brain structures are associated with learning forms exhibiting different levels of ambiguity. In insects, comparable results were found in the case of the honey bee, an insect which has a model status for studies on learning and memory1-4. In particular, pharmacological blocking of the mushroom bodies (MBs), higher-order brain structures associated with memory storage and retrieval1,4 impairs olfactory reversal learning but leaves intact the capacity to achieve two successive elemental olfactory discriminations5.
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DFER has directed more than $17 million into political and grassroots advocacy over three years toward what the group’s executive director Joe Williams describes as “creating momentum which has the potential to dominate education policy-making for years to come.” Education Reform Now is DFER’s nonprofit sister organization, also headed by Williams.
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Featured ArticleArticles, Behavioral/Systems/Cognitive Such aggressive self-documentation could come seem rote and flat, or could be, as is the case here, an act of thoughtful daring and vulnerability. Throughout, Guérin reveals her own preoccupations (e.g. the abstract hat shape to which she keeps returning in her work), exasperations, and ephemeral preferences. "I wish things would go faster" she writes, just below a fragment that says "Liking brown right now — or more precisely, to brown my colors," which in turn is not too far below a fragment that reads like a poem:
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YVES SAINT LAURENT You have already created this alert. Time: 13:30 – 14:15 Wednesday, 22nd July Attorney General Unprecedented sums from Stand for Children that poured into 2010 Illinois legislative races bought legislation opposing basic teacher protection. Guerin Lee Green of Cherry Creek News writes, the group’s executive director Jonah Edelman subsequently boasted about the purpose of spending such huge sums of money: “...individual candidates were essentially a vehicle to execute a political objective” — an assault on traditional public education — “luckily it never got covered that way” as “the press never picked up on” that.
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80%↑ Purse Bill Guerin, Tony Amonte and Doug Weight played as an all-American line, combining for 13 points (six goals and seven assists). In his All-Star Game debut, Guerin recorded a hat-trick and added two assists, capturing MVP honors. The North America All-Stars defeated the World All-Stars 14–12, setting a new All-Star Game record for most goals scored by both teams in one game (26).
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