That prompted the Oct. 16 email to DPS staff and others, this one purporting to come from “email@example.com” and describing Suppes’ email as “spam.” At the end of the lengthy email, which is critical of the district and its bond proposal, is the signoff: “Not the real Mary Seawell (obviously).”
Confirm Featured content Cognition is built on dedicated subsystems: sensory input, evaluation, memory, action selection and ultimately behavioral control. In the olfactory system, attributing a meaning to an olfactory stimulus relies on odor identification. Odor meaning can be coded in evolution (innate systems), or in a lifetime (learned odors), with both systems working in parallel within most animals. However, no sensory system can be understood without understanding all of the sensory input that reaches the brain. This is particularly true for a system that is fundamentally combinatorial, such as the olfactory system. Even though there are situations where all the relevant information about the outside world resides in single information channels (e.g. by activating a pheromone receptor, the presence of that pheromone is conveyed without ambiguity), in most cases, the picture is more complex (e.g., the same pheromone in the wrong olfactory environment will not elicit the same response). The combinatorial nature of olfactory coding has one difficult consequence: no lab will be able to record all responses in all neurons to all possible olfactory stimuli. Therefore, we need a platform that can combine data from different laboratories, using different recording approaches, in order to build a consensus database.
On January 27, Wagner wrote a blog diary on ColoradoPols called, "The Great Attempt to DeFEND the Morally Indefensible." In it, she questioned who was behind the recall and pointed the finger at DeFENSE, a group whose website doesn't overtly name the names of those involved. From Wagner's diary:
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Your lists Get the first crack at VideoPal http://cli.re/videopal No on Denver 3B, a group organized to fight the bond proposal, has denied any involvement in the emails sent to DPS staff and others. Earleen Brown, a spokeswoman for the group, said, “We have attached our name to all communications from the campaign.”
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SIRT-KO mice are markedly impaired in associative memory. A , SIRT1-KO mice show slightly higher activity (n = 4 per genotype; WT, 5.5 ± 0.6 cm/s; KO, 8 ± 1.2 cm/s; *p < 0.05) yet similar responses to electric shock than WT mice during training. B, C , Conditioning to context short term ( B ) (n = 4 per genotype; WT, 49 ± 7%; KO, 14 ± 9%; *p < 0.05) and long term ( C ) (WT, n = 13, 48 ± 6%; KO, n = 10, 4 ± 1.5%; **p < 0.001). D , Freezing to altered context did not reveal differences between genotypes (WT, n = 13; KO, n = 10). In contrast to SIRT1-KO, wild-type mice show significantly decreased fear responses in the altered context compared with that in the training context (6 ± 3 vs 48 ± 6%, respectively; p < 0.001). E , In conditioning to tone, SIRT1-KO mice (n = 10; 14 ± 4%) also displayed decreased performance compared with WT mice (n = 13; 31 ± 6%; *p < 0.05). Data represent means ± SEM.
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Journal of Neuroscience 21 July 2010, 30 (29) 9695-9707; DOI: https://doi.org/10.1523/JNEUROSCI.0027-10.2010
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