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SIRT-KO mice are markedly impaired in associative memory. A , SIRT1-KO mice show slightly higher activity (n = 4 per genotype; WT, 5.5 ± 0.6 cm/s; KO, 8 ± 1.2 cm/s; *p < 0.05) yet similar responses to electric shock than WT mice during training. B, C , Conditioning to context short term ( B ) (n = 4 per genotype; WT, 49 ± 7%; KO, 14 ± 9%; *p < 0.05) and long term ( C ) (WT, n = 13, 48 ± 6%; KO, n = 10, 4 ± 1.5%; **p < 0.001). D , Freezing to altered context did not reveal differences between genotypes (WT, n = 13; KO, n = 10). In contrast to SIRT1-KO, wild-type mice show significantly decreased fear responses in the altered context compared with that in the training context (6 ± 3 vs 48 ± 6%, respectively; p < 0.001). E , In conditioning to tone, SIRT1-KO mice (n = 10; 14 ± 4%) also displayed decreased performance compared with WT mice (n = 13; 31 ± 6%; *p < 0.05). Data represent means ± SEM.
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✔ In Play Later I doubt anyone knows how or why this happens: all the silver and red maples in the region are laden with so much fruit it is hard to pick out any leaves. How can this phenomenon be coordinated among all the trees? One client called yesterday and asked how to spell the word ‘schizocarp.’ I […]
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I’ve read a bit on this whole DEFENSE thing that this seems to stem from — yeah it seems super shady of them not to explain who is running the group, but isn’t it also shady for you to run a site like this without saying who you are?
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