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The lack of SIRT1 does not affect exploratory behavior but leads to deficits in immediate memory. A, B , SIRT1-KO mice showed normal exploratory behavior in the open field compared with WT as revealed by distance traveled ( A ) and time spent in the center of the arena ( B ) (n = 4 per genotype; WT, 3.6 ± 1. 05%; KO, 3.4 ± 1.5%). C , Novel object recognition test shows normal discriminatory ability to a novel object in SIRT1-KO mice (n = 4 per genotype; training WT, 7 ± 5; training KO, 12 ± 6; test WT, 30 ± 12; KO test, 40 ± 13; p > 0.5). D , Decreased spontaneous alternation in the Y maze compared with WT mice (n = 16 per genotype; WT 58 ± 4 vs KO 48 ± 2%; *p < 0.05). Data represent means ± SEM. E , Cross sections of retinas from SIRT1-KO and WT mice show normal morphology of all retinal layers (ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer) by hematoxylin and eosin staining as well as by isolectin (red), GFAP (green), and DAPI (blue) staining ( F ). Scale bars, 100 μM.
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The 2000–01 season was highlighted by the return of Mario Lemieux. After three-and-a-half years in retirement, Lemieux returned to NHL action and with it came a selection to his ninth NHL All-Star Game. Notching a goal and an assist for the North America All-Stars, Lemieux's All-Star totals climbed to 12 goals and 10 assists for 22 points. He trails only Wayne Gretzky for the All-Star Game's all-time leading scoring title (13–12–25).
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Such aggressive self-documentation could come seem rote and flat, or could be, as is the case here, an act of thoughtful daring and vulnerability. Throughout, Guérin reveals her own preoccupations (e.g. the abstract hat shape to which she keeps returning in her work), exasperations, and ephemeral preferences. "I wish things would go faster" she writes, just below a fragment that says "Liking brown right now — or more precisely, to brown my colors," which in turn is not too far below a fragment that reads like a poem:
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In her "Intro," entitled "This Book is a Painting," Guérin discusses how initially, the material for this book came from her desire to "better understand the evolution of the work (and keep track of my studio time)" and then how, upon copying and recopying it for subsequent purposes, "transcribing my notes was a meditative activity."
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