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Content Guidelines 10%↑ Denver Direct - Beds | 2 Baths | 1729 Sq. Ft. The effort to recall Denver Public Schools board president Nate Easley has created some odd side dramas. One of them resulted in the outing of Linda Wagner, an Estes Park doggie day care owner and staunch Democrat who blogs on ColoradoPols under the pseudonym "Middle of the Road." Or did, until Guerin Lee Green, the publisher of the Cherry Creek News, publicly unmasked her after she wrote a piece critical of DeFENSE, a group that's trying to oust Easley.
Overexpression of SIRT1 in hippocampus does not alter LTP or associative memory. A , Western blot shows ∼16-fold SIRT1 protein increase in hippocampus of NeSTO mice compared with control Nestin–Cre animals. The numbers below show SIRT1 levels relative to actin. B , I/O curve of field EPSP slope versus current input (microamperes) is shifted to the left in NeSTO mice (n = 14; gray circles) compared with Nestin–Cre (n = 10; black circles; p < 0.0001, two-way ANOVA), suggesting increased basal synaptic excitability. C , Paired-pulse facilitation reveals normal presynaptic events in NeSTO mice (n = 5 each genotype). D , Similar LTP was elicited by 5 × 3 and 10 × 10 TBS (EPSP slopes; n = 7 each genotype) in mice overexpressing wild-type or increased levels of SIRT1. E, F , Fear conditioning to context ( E ) or tone ( F ) in Nestin–Cre (n = 14) and NeSTO animals (n = 18) show similar associative learning capacities in both strains. Data represent means ± SEM.
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Copyright © 2018 Buzzfile Media LLC. All Rights Reserved. Ph. 303-327-7220 ► December (1) Stroebe, W. (2012). The truth about triplett (1898), but nobody seems to care. Perspect. Psychol. Sci. 7, 54–57. doi: 10.1177/1745691611427306
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