Age ~23 (970) 443-4259 FIFA Women's World Cup Overexpression of SIRT1 in hippocampus does not alter LTP or associative memory. A , Western blot shows ∼16-fold SIRT1 protein increase in hippocampus of NeSTO mice compared with control Nestin–Cre animals. The numbers below show SIRT1 levels relative to actin. B , I/O curve of field EPSP slope versus current input (microamperes) is shifted to the left in NeSTO mice (n = 14; gray circles) compared with Nestin–Cre (n = 10; black circles; p < 0.0001, two-way ANOVA), suggesting increased basal synaptic excitability. C , Paired-pulse facilitation reveals normal presynaptic events in NeSTO mice (n = 5 each genotype). D , Similar LTP was elicited by 5 × 3 and 10 × 10 TBS (EPSP slopes; n = 7 each genotype) in mice overexpressing wild-type or increased levels of SIRT1. E, F , Fear conditioning to context ( E ) or tone ( F ) in Nestin–Cre (n = 14) and NeSTO animals (n = 18) show similar associative learning capacities in both strains. Data represent means ± SEM.
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By THE ASSOCIATED PRESSJuly 25, 2013 at 2:25 am supplemental material - Supplemental Material Nate Easley recall: Anonymous ColoradoPols blogger who wrote about it publicly outed
I wish I could tell you I got everything I wanted for Easter but that wouldn’t be true because I didn’t get a ostrich, which was rude. But other than that the day went pretty well and we had lots of nice food and things.
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Scottish Premier League Social facilitation studies in rhesus macaques are few and far between; only three have been conducted over the last 80 years (Harlow and Yudin, 1933; Stamm, 1961; Ferrari et al., 2005). Two (Harlow and Yudin, 1933; Ferrari et al., 2005) show that macaques eat more in presence of co-eaters than alone (as do humans, Herman, 2015, or capuchin monkeys, Visalberghi and Addessi, 2000; Dindo and de Waal, 2007). The remaining one (Stamm, 1961) provides the proof of concept that the presence of a co-performer also helps macaques when food serves as a reward for a cognitive task rather than being simply made available for consumption (a change recently reported in capuchins as well; Dindo et al., 2009). The aim of the present study was to complete the patchy knowledge of social facilitation in macaques in two ways. First, we wanted to confirm Stamm's early (Stamm, 1961) demonstration of a social facilitation of cognition. Second, we wanted to establish that the present other needs not be a co-performer for the change to occur, and that a simple spectator suffices. To this aim, seven adult rhesus macaques (two dyads and one triad), trained to perform a simple cognitive task consisting in touching images to get food rewards, were alternatively tested alone vs. with a familiar companion serving as either a passive spectator or an active co-performer.
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by: Colorado Pols February 15, 2011 at 9:28 PM MDT Show Us Your Bills Here it is directly from Councilwoman Jeanne Faatz, who got her numbers for City Treasury(remember that Faatz chairs the City Council Finance committee)
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Google Plus Lockhart Seven French-born rhesus macaques (Macaca mulatta), aged 4–11 years, participated in the study: two male-female dyads paired in adulthood, unsuccessfully in one case (dyad 1, the two animals were housed side by side but not together due to the male's unpredictable bouts of aggressiveness), successfully in the other case (dyad 2, the two animals had been living together for 3 years at the start of the experiment), and a triad of same-age females living together since birth. The monkeys had free access to water and received normal daily food rations of fresh fruits and monkey chow (40–130 kcal/kg/day) after testing completion. All animals were familiarized with handling and testing procedures for 4 weeks before the present data were collected. Data from the female triad were partially presented in Monfardini et al. (2015) (see next section for detail). Work complied with European Union Directive 2010/63/EU and was approved by French Animal Ethics Committee C2EA42-CELYNE.
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Reversal learning is a task which, unlike elemental learning, requires solving ambiguities about the links between events. In Pavlovian learning, for instance, two levels of stimulus ambiguity are represented by differential and reversal conditioning. In differential conditioning, a conditioned stimulus A is associated univocally with an Unconditioned Stimulus (US) while a distinct conditioned stimulus B is unambiguously associated with the absence of US (A+ B-). In reversal conditioning, a first conditioning phase (A+ B-) is followed by a second conditioning phase, which introduces an inversion of stimulus contingencies (A- B+). Thus, the addition of the second phase generates transient stimulus ambiguity (A+ A- and B- B+) that needs to be overcome to solve the problem.
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