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Overexpression of SIRT1 in hippocampus does not alter LTP or associative memory. A , Western blot shows ∼16-fold SIRT1 protein increase in hippocampus of NeSTO mice compared with control Nestin–Cre animals. The numbers below show SIRT1 levels relative to actin. B , I/O curve of field EPSP slope versus current input (microamperes) is shifted to the left in NeSTO mice (n = 14; gray circles) compared with Nestin–Cre (n = 10; black circles; p < 0.0001, two-way ANOVA), suggesting increased basal synaptic excitability. C , Paired-pulse facilitation reveals normal presynaptic events in NeSTO mice (n = 5 each genotype). D , Similar LTP was elicited by 5 × 3 and 10 × 10 TBS (EPSP slopes; n = 7 each genotype) in mice overexpressing wild-type or increased levels of SIRT1. E, F , Fear conditioning to context ( E ) or tone ( F ) in Nestin–Cre (n = 14) and NeSTO animals (n = 18) show similar associative learning capacities in both strains. Data represent means ± SEM.
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Wool Posted on April 17, 2013 by ColoradoPeakPolitics Licensed (D) Dave Young*
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Start Selling Cherry Creek News Tell Your Story LANVIN Green, who says he's attended DeFENSE meetings, says he suspects Wagner's diaries are part of a larger effort to quash opposition to reform efforts within DPS. "If you've got a Sideshow Bob blogger out there," he says, "you're only seeing the tip of the iceberg of a huge coordinated effort to push a policy agenda and cover up fiscal mismanagement."
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That same day, ColoradoPols shot back. In a piece called, "Guerin Green is a Journalist Like Colorado Pols is an Apple Pie," the powers-that-be at ColoradoPols questioned why Green would go after an anonymous blogger.
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2.3 mi. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Gastroenterology - Pediatric, Pediatrics
Shorts Guerin was a two-time Stanley Cup champion and four-time NHL All-Star during. He and Weight helped the U.S. win silver at the 2002 Olympics. Weight won a Stanley Cup and was a four-time NHL All-Star.
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Advertise on ESPN.com ESPN Daily Calendar The animals completed on average 19 sessions (range 16–20) in the alone condition, 15 sessions (10–21) in the audience condition, and 11 sessions (8–17) in the coaction condition. The monkeys touched the images on the screen to obtain a food treat twice more often under audience and coaction than under alone testing [F(2, 12) = 16.0; p = 0.001; Figure 2A]. Each social condition differed from the alone condition (audience: p = 0.009, coaction: p = 0.002), while not differing from each other (p = 0.80). Effect sizes were systematically superior to the 0.8 value reflecting a large effect (Lakens, 2013). Cohen's d amounted to 1.4 for audience and 1.8 for coaction, and Cohen's Drm to 1.3 for audience and 1.6 for coaction.
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