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9,242 ▾ Discover February 15, 2011 at 10:39 PM MDT Figure 2. Response rate (mean ± sem) for the group (A) and for each individual (B). In (B), scores are illustrated for the alone condition (Al, dark gray bars), the two social conditions taken together (Soc, light gray bars), and for audience (o) and coaction (•) separately. ***p ≤ 0.001, *p ≤ 0.05.
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3 – D Rob Blake (Los Angeles Kings)[2] STELLA MC CARTNEY Arthur Rosenblum Synthetic Overexpression of SIRT1 in hippocampus does not alter LTP or associative memory. A , Western blot shows ∼16-fold SIRT1 protein increase in hippocampus of NeSTO mice compared with control Nestin–Cre animals. The numbers below show SIRT1 levels relative to actin. B , I/O curve of field EPSP slope versus current input (microamperes) is shifted to the left in NeSTO mice (n = 14; gray circles) compared with Nestin–Cre (n = 10; black circles; p < 0.0001, two-way ANOVA), suggesting increased basal synaptic excitability. C , Paired-pulse facilitation reveals normal presynaptic events in NeSTO mice (n = 5 each genotype). D , Similar LTP was elicited by 5 × 3 and 10 × 10 TBS (EPSP slopes; n = 7 each genotype) in mice overexpressing wild-type or increased levels of SIRT1. E, F , Fear conditioning to context ( E ) or tone ( F ) in Nestin–Cre (n = 14) and NeSTO animals (n = 18) show similar associative learning capacities in both strains. Data represent means ± SEM.
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