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► January (10) February 16, 2011 at 12:46 AM MDT ► April (32) In mammals, different brain structures are associated with learning forms exhibiting different levels of ambiguity. In insects, comparable results were found in the case of the honey bee, an insect which has a model status for studies on learning and memory1-4. In particular, pharmacological blocking of the mushroom bodies (MBs), higher-order brain structures associated with memory storage and retrieval1,4 impairs olfactory reversal learning but leaves intact the capacity to achieve two successive elemental olfactory discriminations5.
But they were just profanity-spewing University of Colorado film students struggling to make their first movie — Alferd Packer: The Musical — when Westword interviewed them back in 1993. As an anniversary present, we've resurrected the interview, which is now posted at www.westword.com.
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This isn't about the Senate primary. If it was, I never would have publicly defended Andrea Merida against the recall attempt on her last fall. This is about exactly what I wrote.
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Copyright / IP Policy NASCAR Here we aimed at uncovering the mechanisms underlying the implication of MBs in reversal learning. We reasoned that GABAergic feedback from the output region back to the input region of the MBs might be crucial to inhibit responses to previously reinforced odors during the reversal phase. We thus performed pharmacological experiments blocked GABAergic signaling in the MBs during olfactory reversal learning, by locally injecting antagonists of ionotropic or metabotropic GABA receptors, into the calyces or the vertical lobes. Our results show that GABAergic signaling is required for reversal learning but is dispensable for elemental learning. We thus provide a circuit-based explanation of the implication of MBs role in reversal learning.
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