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MARC JACOBS Obama SIRT-KO mice are markedly impaired in associative memory. A , SIRT1-KO mice show slightly higher activity (n = 4 per genotype; WT, 5.5 ± 0.6 cm/s; KO, 8 ± 1.2 cm/s; *p < 0.05) yet similar responses to electric shock than WT mice during training. B, C , Conditioning to context short term ( B ) (n = 4 per genotype; WT, 49 ± 7%; KO, 14 ± 9%; *p < 0.05) and long term ( C ) (WT, n = 13, 48 ± 6%; KO, n = 10, 4 ± 1.5%; **p < 0.001). D , Freezing to altered context did not reveal differences between genotypes (WT, n = 13; KO, n = 10). In contrast to SIRT1-KO, wild-type mice show significantly decreased fear responses in the altered context compared with that in the training context (6 ± 3 vs 48 ± 6%, respectively; p < 0.001). E , In conditioning to tone, SIRT1-KO mice (n = 10; 14 ± 4%) also displayed decreased performance compared with WT mice (n = 13; 31 ± 6%; *p < 0.05). Data represent means ± SEM.
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First Person is also a platform to influence policy. Recent high school graduate Anisah Karim described the pressure she felt to apply to 100 colleges in the quest for millions of dollars in scholarships. Because of her piece, the school board in Memphis is reviewing the so-called “million-dollar scholar” culture at some high schools.
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