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Burst responses in field CA1 of hippocampal slices from SIRT1-KO and NeSTO mice. Two different protocols of TBS, followed by 40 min of test-pulse recording were used. A , 5 × 3 TBS, five bursts at 5 Hz (theta burst), each burst consisting of three pulses at 100 Hz. B , 10 × 10 TBS, 10 theta bursts, each burst consisting of 10 pulses at 100 Hz. The duration of each pulse within TBS was double that of the test pulse. For each burst response during LTP induction, the area under the curve was measured and each burst area was normalized to the first burst area. (The bottom panels of simulated responses were not scaled.) C, D SIRT1-KO (open circles) and WT (filled circles) burst responses elicited by 5 × 3 TBS ( C ) and 10 × 10 TBS ( D ). E, F , NeSTO (gray bars) and Nestin–Cre (black bars) burst responses elicited by 5 × 3 TBS ( E ) and 10 × 10 TBS ( F ) (p < 0.005, two-way ANOVA). Data represent mean ± SEM.
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Reader: Writing for the Post Is as Much of a... Single Family Pittsburgh Green Garage Initiative ► December (12)
City & County of Denver View Blog Green reports that then-Denver Public Schools Superintendent (now Senator) Michael Bennet approached Republican oilman (now-University of Colorado president) Bruce Benson several years ago, opening the floodgates to unprecedented campaign contributions to Denver school board races by large Republican donors.
Pittsburgh Steelers Listed by Gregg Handrich • Gregg Handrich ROMEO GIGLI DFER has directed more than $17 million into political and grassroots advocacy over three years toward what the group’s executive director Joe Williams describes as “creating momentum which has the potential to dominate education policy-making for years to come.” Education Reform Now is DFER’s nonprofit sister organization, also headed by Williams.
Guerin (2) (Amonte) 14:36 2nd As evoked in the Introduction, neuroimaging could help solve the riddle of social facilitation mediator (Monfardini et al., 2015). Monkeys present an advantage over humans in this new endeavor: the large effect sizes they display (> 1.2 standard deviation unit), well above the modest effect sizes typically observed in humans (~0.3 standard deviation unit; Bond and Titus, 1983). The amplitude of the neural changes revealed by neuroimaging being correlated with the amplitude of the accompanying behavioral changes (Monfardini et al., 2015), the neural signature of social facilitation could be easier to uncover in monkeys than in humans. Regarding behavior, rhesus macaques might help explore moderators of social facilitation that have heretofore been neglected. The variations observed here, across groups (greater facilitation in lifetime female companions), and across individuals (greater audience effect in a subdued female, vs. greater coaction effect in an assertive male), respectively suggest a moderating influence of the observer-observee degree of familiarity (Herman, 2015), and a moderating influence of gender and/or personality traits (Uziel, 2007) for future studies to investigate in larger samples of animals.
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Industry ► December (13) People like Guerin do hit and run pieces all the time, with the full expectation that folks will back down out of fear of intimidation and harassment, the likes of which we now have recorded.
Colorado News Perth Ok, done! Blog Magalie Guerin's "Notes On" coincides with her new exhibit, "Copy Drawings," that will run through May 14 (Magalie Guerin)
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