Burst responses in field CA1 of hippocampal slices from SIRT1-KO and NeSTO mice. Two different protocols of TBS, followed by 40 min of test-pulse recording were used. A , 5 × 3 TBS, five bursts at 5 Hz (theta burst), each burst consisting of three pulses at 100 Hz. B , 10 × 10 TBS, 10 theta bursts, each burst consisting of 10 pulses at 100 Hz. The duration of each pulse within TBS was double that of the test pulse. For each burst response during LTP induction, the area under the curve was measured and each burst area was normalized to the first burst area. (The bottom panels of simulated responses were not scaled.) C, D SIRT1-KO (open circles) and WT (filled circles) burst responses elicited by 5 × 3 TBS ( C ) and 10 × 10 TBS ( D ). E, F , NeSTO (gray bars) and Nestin–Cre (black bars) burst responses elicited by 5 × 3 TBS ( E ) and 10 × 10 TBS ( F ) (p < 0.005, two-way ANOVA). Data represent mean ± SEM.
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The 2000–01 season was highlighted by the return of Mario Lemieux. After three-and-a-half years in retirement, Lemieux returned to NHL action and with it came a selection to his ninth NHL All-Star Game. Notching a goal and an assist for the North America All-Stars, Lemieux's All-Star totals climbed to 12 goals and 10 assists for 22 points. He trails only Wayne Gretzky for the All-Star Game's all-time leading scoring title (13–12–25).
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What’s your point? I’m not saying that in a snarky way, I just don’t understand. Are you saying that we should all post under our real names? That’s not going to happen.
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When I was moving to a new apartment in 2004, I was so happy about the relatively low price of the apartment. Who would have thought that my neighbors would be such a noisy family? That's when I got the idea that it would be nice to get to know your neighbors in advance. Property owners rarely tell the truth about the neighbors and neighborhood.
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“In my classroom discussions, the impetus for the Civil War was resigned to a debate over the balance of power between federal and state governments. Slavery was taught as a footnote to the cause of the war.” —Laura Faith Kebede
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I spoke about it myself in my own diary. And thanks much for all of your great comments, PC. Really appreciate all of them.
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