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Here we aimed at uncovering the mechanisms underlying the implication of MBs in reversal learning. We reasoned that GABAergic feedback from the output region back to the input region of the MBs might be crucial to inhibit responses to previously reinforced odors during the reversal phase. We thus performed pharmacological experiments blocked GABAergic signaling in the MBs during olfactory reversal learning, by locally injecting antagonists of ionotropic or metabotropic GABA receptors, into the calyces or the vertical lobes. Our results show that GABAergic signaling is required for reversal learning but is dispensable for elemental learning. We thus provide a circuit-based explanation of the implication of MBs role in reversal learning.
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You may have been following the strange, bizarre saga of a Denver School Board Member recall and the threats by the editor and publisher of two local newspapers to a couple of Polsters. (*We should note, by the way, that we have never written one word about this attempted recall — a few people have done so via diaries, but Colorado Pols has never weighed in on the issue one way or the other).
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2199 S University Boulevard $770,000 As evoked in the Introduction, neuroimaging could help solve the riddle of social facilitation mediator (Monfardini et al., 2015). Monkeys present an advantage over humans in this new endeavor: the large effect sizes they display (> 1.2 standard deviation unit), well above the modest effect sizes typically observed in humans (~0.3 standard deviation unit; Bond and Titus, 1983). The amplitude of the neural changes revealed by neuroimaging being correlated with the amplitude of the accompanying behavioral changes (Monfardini et al., 2015), the neural signature of social facilitation could be easier to uncover in monkeys than in humans. Regarding behavior, rhesus macaques might help explore moderators of social facilitation that have heretofore been neglected. The variations observed here, across groups (greater facilitation in lifetime female companions), and across individuals (greater audience effect in a subdued female, vs. greater coaction effect in an assertive male), respectively suggest a moderating influence of the observer-observee degree of familiarity (Herman, 2015), and a moderating influence of gender and/or personality traits (Uziel, 2007) for future studies to investigate in larger samples of animals.
► December (38) Related changes supplemental material - Supplemental Material This workshop will discuss how invertebrate brains may provide useful models of the bases of cognition, in spite of their limited size and apparently limited cognitive abilities. Important aspects of the discussion will be how minimal cognitive substrates (micro-brains) can, in conjunction with embodiment, lead to surprisingly sophisticated behaviours, and what lessons we can draw from these examples for the general understanding of cognition. The workshop should be exciting to the computational neuroscience community, because it brings together ideas of full-brain models, embodied cognition, and promising new technologies in the form of GPU super-computing and autonomous robotics.
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Something went wrong while displaying this webpage. SOLD 4/03/18 Ostensibly disavowing partisan politics after his appointment as UC president, Bruce Benson asserted he contributed as a “private citizen” to supposedly nonpartisan school board elections. It is difficult to regard Benson in any way “nonpartisan.” Among his highly partisan roles, he served as chair and principal funding source of the purportedly nonpartisan, tax-exempt non-profit term limits group, Americans Back in Charge. In 1996 the group mounted a highly partisan $3 million “voter education” project using radio broadcasts and direct mail campaigns to advise voters against reelection of 14 House opponents of term limits — all were Democrats. Forty Republicans who has also voted against term limits were not likewise targeted (Rocky Mountain News, 3-15-96). Term limits advocacy, transformed into a partisan weapon to target Democrats, was ultimately abandoned by many early Republican backers once Republicans became the congressional majority.
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