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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. vimeo.com Lack of SIRT1 decreases hippocampal synaptic plasticity. A , I/O plots of field EPSP slopes versus current input (microamperes) were similar in WT (n = 7; filled circles) and SIRT1-KO (n = 8; open circles) mice, indicating that lack of SIRT1 does not alter baseline synaptic transmission. B , Paired-pulse facilitation (n = 3 each genotype) shows similar presynaptic plasticity in WT and SIRT1-KO mice. C , LTP in hippocampal CA1 field elicited by 5 × 3 and 10 × 10 TBS (EPSP slopes; WT, n = 5, filled circles; SIRT1-KO mice, n = 7, open circles). Five burst of 3 × 100 Hz stimulation evokes LTP in both genotypes, whereas 10 bursts of 10 × 100 Hz trains stimulation leads to a long-lasting form of LTP in control but not in SIRTI-KO mouse. D , EPSP slopes averages during the first 2 min after TBS (short-term potentiation) were similar in both genotypes. E , EPSP slopes averages 30–40 min after applying the 10 × 10 TBS protocol show significant differences in LTP induction in WT animals compared with SIRT1-KO mice (*p < 0.05, t test). Data represent means ± SEM. Neuronline 303-922-0589 ►  November (31) New England Patriots Colorado and Company Media Relations Anaheim Ducks Industry Dear , Your request to remove the company profile has been denied for: You are only permitted to claim ownership and remove one company profile. You have previously claimed ownership and removed the profile for: You can contact us at [email protected] with any questions. 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