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► February (33) Create Podcast Campus Box 57 Shelby Burst responses in field CA1 of hippocampal slices from SIRT1-KO and NeSTO mice. Two different protocols of TBS, followed by 40 min of test-pulse recording were used. A , 5 × 3 TBS, five bursts at 5 Hz (theta burst), each burst consisting of three pulses at 100 Hz. B , 10 × 10 TBS, 10 theta bursts, each burst consisting of 10 pulses at 100 Hz. The duration of each pulse within TBS was double that of the test pulse. For each burst response during LTP induction, the area under the curve was measured and each burst area was normalized to the first burst area. (The bottom panels of simulated responses were not scaled.) C, D SIRT1-KO (open circles) and WT (filled circles) burst responses elicited by 5 × 3 TBS ( C ) and 10 × 10 TBS ( D ). E, F , NeSTO (gray bars) and Nestin–Cre (black bars) burst responses elicited by 5 × 3 TBS ( E ) and 10 × 10 TBS ( F ) (p < 0.005, two-way ANOVA). Data represent mean ± SEM.
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2 Highlights BUY AND SELL PRE-OWNED LUXURY FASHION Seven pictures of neutral objects (e.g., an armchair, a farm tractor, a knit cap) were pseudo-randomly presented on the right or on the left side of the screen always in the same order. Touching the image led to a positive visual feedback plus a reward (~5 tiny beads of dry pasta); the trial time course (Figure 1A) allowed a maximum response rate of 8 responses/min. Each testing session lasted 15 min. For social testing, two animals were placed side by side; each monkey could see and hear the other one but not reach the other's screen or treats. The animals first alternated 1 day alone (Figure 1B), 1 day in the passive presence of a housemate (or neighbor for dyad 1; audience, Figure 1C), and then 1 day alone, 1 day in the presence of a housemate/neighbor doing the same task (coaction, Figure 1D). For the triad, half of the social sessions were carried out in the presence of one partner, the other half in the presence of the other partner; this group's audience scores were included in Monfardini et al. (2015) where they were correlated with changes in brain metabolism and changes in plasma cortisol level.
We thank Ivan Balansard for veterinary care; Clément Hynaux for help with data collection; Gislène Gardechaux for animal care; Frédéric Volland, Roméo Salemme, and Eric Koun for technical and engineering assistance.
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