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Phil Goodstein Followers 79 Film Reviews As evoked in the Introduction, neuroimaging could help solve the riddle of social facilitation mediator (Monfardini et al., 2015). Monkeys present an advantage over humans in this new endeavor: the large effect sizes they display (> 1.2 standard deviation unit), well above the modest effect sizes typically observed in humans (~0.3 standard deviation unit; Bond and Titus, 1983). The amplitude of the neural changes revealed by neuroimaging being correlated with the amplitude of the accompanying behavioral changes (Monfardini et al., 2015), the neural signature of social facilitation could be easier to uncover in monkeys than in humans. Regarding behavior, rhesus macaques might help explore moderators of social facilitation that have heretofore been neglected. The variations observed here, across groups (greater facilitation in lifetime female companions), and across individuals (greater audience effect in a subdued female, vs. greater coaction effect in an assertive male), respectively suggest a moderating influence of the observer-observee degree of familiarity (Herman, 2015), and a moderating influence of gender and/or personality traits (Uziel, 2007) for future studies to investigate in larger samples of animals.
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Partywear New Stingray Overexpression of SIRT1 in hippocampus does not alter LTP or associative memory. A , Western blot shows ∼16-fold SIRT1 protein increase in hippocampus of NeSTO mice compared with control Nestin–Cre animals. The numbers below show SIRT1 levels relative to actin. B , I/O curve of field EPSP slope versus current input (microamperes) is shifted to the left in NeSTO mice (n = 14; gray circles) compared with Nestin–Cre (n = 10; black circles; p < 0.0001, two-way ANOVA), suggesting increased basal synaptic excitability. C , Paired-pulse facilitation reveals normal presynaptic events in NeSTO mice (n = 5 each genotype). D , Similar LTP was elicited by 5 × 3 and 10 × 10 TBS (EPSP slopes; n = 7 each genotype) in mice overexpressing wild-type or increased levels of SIRT1. E, F , Fear conditioning to context ( E ) or tone ( F ) in Nestin–Cre (n = 14) and NeSTO animals (n = 18) show similar associative learning capacities in both strains. Data represent means ± SEM.
Nawrot, M., D’Albis, T., Menzel, R., Strube-Bloss, M. (2015) Neural representation of a spatial odor memory in the honeybee mushroom body. Computational Neuroscience Meeting, July 18-23, Prague, Czech Republic
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