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B , Paired-pulse facilitation (n = 3 each genotype) shows similar presynaptic plasticity in WT and SIRT1-KO mice. C , LTP in hippocampal CA1 field elicited by 5 × 3 and 10 × 10 TBS (EPSP slopes; WT, n = 5, filled circles; SIRT1-KO mice, n = 7, open circles). Five burst of 3 × 100 Hz stimulation evokes LTP in both genotypes, whereas 10 bursts of 10 × 100 Hz trains stimulation leads to a long-lasting form of LTP in control but not in SIRTI-KO mouse. D , EPSP slopes averages during the first 2 min after TBS (short-term potentiation) were similar in both genotypes. E , EPSP slopes averages 30–40 min after applying the 10 × 10 TBS protocol show significant differences in LTP induction in WT animals compared with SIRT1-KO mice (*p < 0.05, t test). Data represent means ± SEM. 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