Does orlistat work for everyone?

Orlistat isn't effective for everyone and is by no means a miracle weight loss pill. Orlistat is recommended if you are overweight and if previous weight-reducing efforts have not worked. As long as you follow a sensible, balanced diet, as well as exercise regularly, you'll have a good chance of losing weight.


Orlistat will usually only be recommended if you've made a significant effort to lose weight through diet, exercise or changing your lifestyle. Even then, orlistat is only prescribed if you have a: body mass index (BMI) of 28 or more, and other weight-related conditions, such as high blood pressure or type 2 diabetes.


Your BMI: Must be 30 or above; or. Must be 28 or above, and you have a medical condition that would benefit from losing weight (such as diabetes or high blood pressure).
You must lose at least 5% of your weight by three months from starting orlistat; if not, treatment should be stopped.


The Food and Drug Administration (FDA) published a safety review of orlistat in 2010 because of rare reports of serious liver injury in people using it. The FDA found no evidence to confirm that orlistat was the cause of the reported liver injuries.
Eat some starchy carbohydrate such as bread, potato, rice and pasta at each meal. These are low in fat and will help to make you feel full. For most people the range is between 12-72 hrs. In clinical studies, once orlistat was stopped, baseline levels returned by about 72 hours.

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Reference

1. Zhi J, Melia AT, Eggers H, Joly R, Patel IH (1995). "Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers". J Clin Pharmacol. 35 (11): 1103–8. doi:10.1002/j.1552-4604.1995.tb04034.x. PMID 8626884.
2. Stylized with a lowercase a on the packaging, and a bar over the i (that is, "allī"), but capitalized conventionally in the manual.
3. Bodkin J, Humphries E, McLeod M (2003). "The total synthesis of (−)-tetrahydrolipstatin". Australian Journal of Chemistry. 56 (8): 795–803. doi:10.1071/CH03121.
4. "US orlistat label" (PDF). FDA. August 2015. Retrieved 18 April 2018. For label updates see FDA index page for NDA 020766