Davis Publications
Professor Emeritus
Department of Biochemisty and Molecular Genetics
RNA Biocience Initiative
University of Colorado School of Medicine
Anschutz Medical Campus
Representative Publications
Estrem, B, Davis, R.E., and J. Wang. 2024. End resection and telomere healing of DNA double-strand breaks during nematode programmed DNA elimination. Nucleic Acids Res. 52, 8913–8929. PDF or Pubmed
Zagoskin, M.V., Wang, J., Neff, A.T., Veronezi, G.M.B., and R.E. Davis. 2022. Small RNA pathways in the nematode Ascaris in the absence of piRNAs. Nature Communications, 13:837. PDF or Pubmed
Carlton, P.M., Davis, R.E., and S. Ahmed. 2022. Nematode Chromosomes. Genetics, WormBook, 10.1093/genetics/iyac014. PDF or PubMed
Wang, J., Veronezi, G.M.B., Kang, Y., Zagoskin, M., O’Toole, E.T., and R.E. Davis. 2020. Comprehensive chromosome end remodeling during programmed DNA elimination. Current Biology, 30: 3397–3413. PDF or Pubmed
Easton, A.V., Gao, S., Lawton, S.P., Bennuru, A., Khan, A., Dahlstrom, E., Oliveira, R.G., Kepha, S.F., Webster, J.P., Anderson, R.M., Grigg, M.E., *Davis, R.E., Wang. J., and T.B. Nutman. 2020. Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans. eLife 2020;9:e61562. *Co-corresponding author PDF or Pubmed
Wang, J. and R.E. Davis. 2020. Ascaris. Current Biology. 30: R423–R42. PDF or Pubmed
Liu, J., Zhu, L., Wang, J., Qiu, L., Chen, Y., Davis, R.E. and G. Cheng. 2019. Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism. PLOS Pathogens, doi.org/10.1371/journal.ppat.1007817. PDF or Pubmed
Wang, J., Gao, S., Mostovoy, Y. Y. Kang, Y., Zagoskin, M., Sun, Y., Zhang, Y, Zhang, B. While, L.K., Eaton, A., Nutman, T., Kwok, P.-Y., Hu, S., Nielsen, M.K. and R.E. Davis. 2017. Comparative genome analysis of programmed DNA elimination in nematodes. Genome Research. 27:2001–2014. PDF or Pubmed
Kang, Y., Wang, J., Neff, A., Kratzer, S., Kimura, H., and R.E. Davis. 2016. Differential chromosomal localization of centromeric histone CENP-A contributes to nematode programmed DNA elimination. Cell Reports. 16:2308–2316. PDF or PubMed
Streit, A., Wang, J., Kang, Y., and R.E. Davis. 2016. Gene silencing and sex determination by programmed DNA elimination in parasitic nematodes. Current Opinion in Microbiology. 32:120–127. PDF or Pubmed
Zhu, L. Zhao, Wang, J., Hu, X., Peng, J., Luo, R., Zhou, C., Liu, J. Lin, J., Jin, Y., Davis*, R.E. and G. Cheng*. 2016. microRNAs are involved in the regulation of ovary development in the pathogenic blood fluke Schistosoma japonicum. PLoS Pathogens 12(2): e1005423. doi:10.1371/journal.ppat.1005423. *Co-corresponding authors. PDF or Pubmed
Wang, J. and. R.E. Davis. 2014. Programmed DNA elimination in multicellular organisms. Current Opinion in Genetics and Development. 27:26-24. PDF.
Wang, J., Garrey, J., and R.E. Davis. 2014. Transcription in pronuclei and one- to four-cell embryos drives early development in a nematode.. Current Biology 24:124-133. PDF or Pubmed. See also Current Biology Highlight of Paper
Wang, J., Mitreva, M.,Berriman, M., Thorne, A., Magrini, V., Koutsovoulos, G., Kumar, S., Blaxter, M.L., and R.E. Davis. 2012. Silencing of germline-expressed genes by DNA elimination in somatic cells. Developmental Cell 23:1072–1080. PDF, Supplementary Material, or Pubmed. See Also Dev Cell Preview on Article and F1000 Prime Recommendation
Wang, J., Czech, B. Crunk, A., Wallace, A., Mitreva, M., Hannon, G., and R.E. Davis. 2011. Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles. Genome Research 21:1462–1477. PDF, Supplementary Material, or Pubmed
Liu, W. ..............Jones, D., R.E. Davis. 2011. Structural Basis for Nematode eIF4E binding an m2,2,7G-Cap and its Implications for Translation Initiation. Nucleic Acids Research 39: 8820–8832. PDF or Pubmed
Wallace, A., Filbin, M., Veo, B., McFarland, C., Jankowska-Anyszka, M., Stepinski, J., Darzynkiewicz, E., and R.E. Davis. 2010. The nematode eIF4E/G complex works with a trans-spliced leader stem loop to enable efficient translation of trimethylguanosine-capped RNAs. Mol. Cell. Biol. 30:1958-1970. PDF or Pubmed
Liu, W., Zhao, R., McFarland, C., Kieft, J., Niedzwiecka, A., Jankowska-Anyszka, M., Stepinski, J., Darzynkiewicz, E., Jones, D.N.M., and R.E. Davis. 2009. Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA cap. J. Biol. Chem. 284:31333-331349. PDF or Pubmed
Kowalska, J., Lewdorowicz, M., Zuberek, J., Grudzien-Nogalska, E., Bojarska, J., Stepinski, J., Rhoads, R.E., Darzynkiewicz, E., Davis, R.E. and Jemielity, J. 2008. Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS. RNA. 14:1-14. PDF or Pubmed
Cheng, G., Cohen, L.S., Mikhli, M., Jankowska-Anyszka, M., Stepinski, J., Darzynkiewicz, E., and R.E. Davis. 2007. In vivo translation and stability of trans-spliced mRNAs in nematode embryo. Mol. Biochem. Parasitol. 153:95-106. PDF or Pubmed
Cheng, G. and R.E. Davis. 2007. An improved and secreted luciferase reporter for schistosomes. Mol. Biochem. Parasitol. 155:167-171. PDF or Pubmed
Cheng, G, Cohen, L, Ndegwa, D., and R.E. Davis. 2006. The flatworm spliced leader 3' terminal AUG as a translation initiator methionine. J. Biol. Chem. 281:733-743. PDF or Pubmed
Lall, S, Piano, F., and R. E. Davis. 2005. C. elegans decapping proteins: Localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis. Mol. Biol. Cell. 16:5880-5890. PDF or Pubmed
Cohen, L.S., Mikhli, M., Jiao, X., Kiledjian, M., Kunkel, G., and R.E. Davis. 2005. Dcp2 Decaps m2,2,7GpppN 5' capped RNAs and its activity is sequence and context dependent. Mol. Cell. Biol. 25:8779-8791. PDF or Pubmed
Blumenthal, T. and R. E. Davis. 2004. Exploring nematode diversity. Nat. Genet. 12:1246-124. PDF or Pubmed
Lall, S., Friedman, C., Jankowska-Anyszka, M., Stepinski, J., Darzynkiewicz, E., and R.E. Davis. 2004. Contribution of trans-splicing, 5' leader length, cap-poly(A) synergism, and initiation factors to nematode translation in an Ascaris suum embryo cell-free system. J. Biol. Chem. 279:45573-45585 PDF or Pubmed (JBC Paper of the Week)
Cohen, L.S., Mikhli, M., Friedman, C., Jankowska-Anyszka, M., Stepinski, J., Darzynkiewicz, E., and R.E. Davis. 2004. Nematode m7GpppG and m32,2,7GpppG Decapping: Activities in Ascaris Embryos and Characterization of C. elegans Scavenger DcpS. RNA 10: 1609-1624. PDF or Pubmed
Davis, R.E., A. Parra, P. LoVerde, E. Ribeiro, G. Glorioso, and S. Hodgson. 1999. Transient expression of RNA and DNA in parasitic helminths by using particle bombardment. Proc. Natl. Acad. Sci. USA 96:8867-8892. PDF or Pubmed
Davis, R.E. and S. Hodgson. 1997. Gene linkage and steady state RNAs suggests trans-splicing may be associated with a polycistronic transcript in the flatworm Schistosoma mansoni. Mol. Biochem. Parasitol. 89:25-39. PDF or Pubmed
Davis, R.E. 1997. Surprising diversity and distribution of SL RNAs in flatworms. Mol. Biochem. Parasitol. 87:29-48. PDF or PubMed
Davis, R.E., C. Hardwick, P. Tavernier, S. Hodgson, and H. Singh. 1995. RNA trans-splicing in flatworms: Analysis of trans-spliced genes and mRNAs in the human parasite, Schistosoma mansoni. J. Biol. Chem. 270:21813-21819. PDF or Pubmed
Davis, R.E., H. Singh, C. Botka, C. Hardwick, A. Meanawy, and J. Villanueva. 1994. RNA trans-splicing in Fasciola hepatica : Identification of an SL RNA and spliced leader sequences on mRNAs. J. Biol. Chem. 269:20026-20031. PDF or Pubmed
Rajkovic, A., R.E. Davis, J.N. Simonsen and F.M. Rottman. 1990. A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni. Proc. Natl. Acad. Sci. 87: 8879-8883. PDF or Pubmed